Investigation of bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor
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چکیده
منابع مشابه
Preparation and evaluation of 67Ga-DOTA-Bombesin (7-14) as a tumor scintigraphic agent
Introduction: Bombesin is a 14-aminoacid peptide isolated from frog skin. The mammalian counterparts of the frog peptide are neuromedin B (NMB) and gastrin-releasing peptide (GRP). Bombesin (BBN) is a peptide showing high affinity for the gastrin releasing peptide receptor (GRPr). Prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over...
متن کاملMolecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide.
The mammalian bombesin peptides [gastrin-releasing peptide (GRP) and neuromedin B (NMB)] are important in numerous biological and pathological processes. These effects are mediated by the heptahelical GRP receptor (GRPR) and NMB receptor (NMBR). GRP has high affinity for GRPR and lower affinity for NMBR. Almost nothing is known about the molecular basis for the selectivity of GRP. To address th...
متن کاملCloning of cDNAs encoding amphibian bombesin: evidence for the relationship between bombesin and gastrin-releasing peptide.
Bombesin is a tetradecapeptide originally isolated from frog skin; its mammalian homologue is the 27-amino acid peptide gastrin-releasing peptide (GRP). cDNAs encoding GRP have been cloned from diverse species, but little is yet known about the amphibian bombesin precursor. Mass spectrometry of HPLC-separated skin exudate from Bombina orientalis was performed to demonstrate the existence of aut...
متن کاملDevelopmental expression and biological activity of gastrin-releasing peptide (GRP) and GRP receptors in the kidney
Mammalian Gastrin Releasing Peptide (GRP) has a widespread distribution and multiple stimulating effects on metabolism, release of regulatory peptides, gastrointestinal and pancreatic secretions, and behaviour. GRP is a potent mitogen for a number of tumor types including colon and lung. Although GRP is known to stimulate the growth of renal tumors, little is known of its synthesis, distributio...
متن کاملpreparation and evaluation of 67ga-dota-bombesin (7-14) as a tumor scintigraphic agent
introduction: bombesin is a 14-aminoacid peptide isolated from frog skin. the mammalian counterparts of the frog peptide are neuromedin b (nmb) and gastrin-releasing peptide (grp). bombesin (bbn) is a peptide showing high affinity for the gastrin releasing peptide receptor (grpr). prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over express receptors to bombesi...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2016
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2016.09.039